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Year : 2019  |  Volume : 2  |  Issue : 2  |  Page : 53-60

Serum l-fucose levels as a potential biomarker in the early detection of oral potentially malignant epithelial lesions and oral squamous cell carcinoma: An original research article

1 Department of Oral Medicine and Radiology, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur, Maharashtra, India
2 Department of Oral Medicine and Radiology, Saraswati Dhanwantari Dental College and Hospital and Post-graduate Research Institute, Parbhani, Maharashtra, India
3 Department of Oral and Maxillofacial Surgery, Sathyabama Dental College and Hospital, Chennai, Tamil Nadu, India
4 Department of Oral and Maxillofacial Surgery, Malla Reddy Dental College for Women, Hyderabad, Telangana, India

Correspondence Address:
Dr. Abhishek Singh Nayyar
Department of Oral Medicine and Radiology, Saraswati-Dhanwantari Dental College and Hospital, Post Graduate Research Institute, Parbhani, Maharashtra.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jco.jco_9_19

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Context and Aim: Tumor markers are specific substances released either by the tumor or, the host while combating the tumor into the serum. Altered concentration of these biomarkers in the serum or, saliva of an individual, then, gives the signal of the future alarming condition pertaining to the process of frank malignant transformations. l-Fucose is one such tumor marker detectable in serum which can be used as an important biomarker for the detection, monitoring and for prognostic assessment of the potentially malignant disorders. The purpose of the present study was to estimate and evaluate the efficacy of serum l-Fucose levels as a potential biomarker in the early detection of oral potentially malignant epithelial lesions (PMELs) including leukoplakia, OSMF and OSCC patients. Materials and Methods: The present observational study was conducted over a period of 2 years wherein a total of 100 subjects aged between 18 to 60 years clinically diagnosed and histopathologically confirmed as patients with oral leukoplakia, OSMF and OSCC between the age range of 20-60 years were included. The patients were subjected to incisional biopsy after routine hematological investigation. The same sera samples were, then, used for the analysis of serum l-Fucose levels. Statistical Analysis Used: The statistical analysis was done using the Statistical Package for Social Sciences (SPSS version 17.0, EPI-INFO 6.0 version) and Graph Pad Prism version 5.0 (Chicago, USA). Comparison of serum L-Fucose levels with the control group was performed using one way Analysis of Variance (one way ANOVA) test (F-Test) while frequencies were compared with the help of chi-square test. Inter-group comparisons and multiple comparisons were done with the help of Tukey’s Test. P < 0.05 was considered statistically significant. Results: On comparing serum l-Fucose levels in the patients of the four groups, a statistically significant difference was found in the values of the mean serum l-Fucose levels in all the four groups (p < 0.05). Conclusion: The observations of the present study revealed that serum l-Fucose levels were found to be raised in all the three groups and showcased an increasing trend with the progression of the severity of the disease from the potentially malignant to the malignant stages.

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