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  Indian J Med Microbiol
 

Figure 2: Structure of the BRAF protein. The conserved regions superimposed on their exonic locations are shown as CR1, CR2, and CR3. S365 in CR2 is the negative regulatory phosphorylation site. The N terminal of kinase domain (KD) comprising SSDD amino acid sequence provides negative charge and phosphorylation site at S446. The S446 phosphorylation is constitutive and necessary for function of kinase domain. T599 and S602 in the activation segment TVKS are the phosphorylation site activated by binding of RAS GTP and are necessary for activation of downstream MEK. RBD = GTP-RAS binding domain, CRD = cysteine-rich domain. (Copyright Dr A. Mehta)

Figure 2: Structure of the BRAF protein. The conserved regions superimposed on their exonic locations are shown as CR1, CR2, and CR3. S365 in CR2 is the negative regulatory phosphorylation site. The N terminal of kinase domain (KD) comprising SSDD amino acid sequence provides negative charge and phosphorylation site at S446. The S446 phosphorylation is constitutive and necessary for function of kinase domain. T599 and S602 in the activation segment TVKS are the phosphorylation site activated by binding of RAS GTP and are necessary for activation of downstream MEK. RBD = GTP-RAS binding domain, CRD = cysteine-rich domain. (Copyright Dr A. Mehta)