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  Indian J Med Microbiol
 

Figure 5: The sequence of events in CIMP pathway of colorectal carcinogenesis. Note the CRC precedes sessile serrated adenoma (SSA). Please also note that nearly 75% of CIMP CRC are associated with BRAF V600E mutation. P16ink4and P14ARF are tumor suppressor genes and THBS1 and COX2 are oncogenes. While the former undergo loss of function mutations the latter are mutated to overactive state

Figure 5: The sequence of events in CIMP pathway of colorectal carcinogenesis. Note the CRC precedes sessile serrated adenoma (SSA). Please also note that nearly 75% of CIMP CRC are associated with <i>BRAF V600E</i> mutation. <i>P16ink</i><sup><i>4</i></sup>and <i>P14ARF</i> are tumor suppressor genes and <i>THBS1</i> and <i>COX2</i> are oncogenes. While the former undergo loss of function mutations the latter are mutated to overactive state